Date of Award

1-1-2015

Document Type

Dissertation

Degree Name

Ph.D.

Organizational Unit

Chemistry and Biochemistry

First Advisor

Andrei Kutateladze, Ph.D.

Second Advisor

Phillip Danielson

Third Advisor

Bryan Cowen

Fourth Advisor

Gareth Eaton

Fifth Advisor

Martin Margittai

Keywords

Azaxylylene, Chemistry, Mechanism, Organic, Photochemistry, Suzuki

Abstract

This research sets out to build upon excited state o-azaxylylene cycloaddition. The mechanism behind the excitation and cycloaddition process of photogenerated o-azaxylylenes was determined experimentally. Time-correlated single-photon counting, steady-state spectroscopy, triplet quenching experiments, and quantum yield studies provided evidence suggesting that excited state intramolecular proton transfer is followed by intersystem crossing and stepwise addition to the tethered unsaturated pendant.

In keeping with the principles of diversity oriented synthesis, a modular approach was taken to gain access to a diverse array of N,O,S-Polyheterocycles which were modified postphotochemically via Suzuki coupling to yield fused biaryls. Cycloaddition products, outfitted with halogens in the aromatic ring of the o-azaxylylene, proved to be reactive with a variety of boronic acids resulting in a rapid growth in structural complexity.

A novel procedure was developed that utilized multiple o-azaxylylene cores in a photochemical cascade transformation yielding complex scaffolds of unprecedented topology. The photoprecursors were produced in a one-pot two-step sequence from commercially available starting materials, and upon irradiation yield structures containing up to five fused hetrocyclic rings, and showed complete diastereoselectivity.

Publication Statement

Copyright is held by the author. User is responsible for all copyright compliance.

Rights Holder

William Cole Cronk

Provenance

Received from ProQuest

File Format

application/pdf

Language

en

File Size

136 p.

Discipline

Organic Chemistry

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