Date of Award

1-1-2016

Document Type

Thesis

Degree Name

M.S.

Department

Chemistry and Biochemistry

First Advisor

Brian W. Michel

Keywords

8-Vinylquinoline, Alkene, Catalyzed, Difunctionalization, Oxidation, Palladium

Abstract

The synthesis of quinoline derivatives is a continuing issue facing organic chemists in both academia and industry. To address this problem, palladium-catalyzed alkene difunctionalization was developed to be a powerful and straightforward strategy of synthetic transformations for adding diversity to organic molecules. In this thesis, Pd-catalyzed olefin difunctionalization reactions of vinyl-quinoline type substrate via generating Pd-alkyl intermediates were mainly described. The reactions described herein are pursuing three significant goals: 1) to isolate and recrystallize Pd-alkyl complexes; 2) to achieve oxidation reactions on Pd-alkyl intermediate; and 3) to investigate stereochemistry of nucleopalladation step on vinyl-quinoline starting materials.

Provenance

Recieved from ProQuest

Rights holder

Lusha Xu Xu

File size

54 p.

File format

application/pdf

Language

en

Discipline

Chemistry

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