Title

Data for Amino Acid Alignment of Japanese Stingray Melanocortin Receptors with other Gnathostome Melanocortin Receptor Sequences, and the Ligand Selectivity of Japanese Stingray Melanocortin Receptors

Document Type

Article

Publication Date

4-26-2016

Keywords

Adrenocorticotropic hormone (ACTH), Dasyatis akajei, Melanocortin receptor (MCR), Melanocyte-stimulating hormone (MSH), Stingray

Organizational Units

College of Natual Science and Mathematics, Biological Sciences

Abstract

This article contains structure and pharmacological characteristics of melanocortin receptors (MCRs) related to research published in “Characterization of melanocortin receptors from stingray Dasyatis akajei, a cartilaginous fish” (Takahashi et al., 2016) [1]. The amino acid sequences of the stingray, D. akajei, MC1R, MC2R, MC3R, MC4R, and MC5R were aligned with the corresponding melanocortin receptor sequences from the elephant shark, Callorhinchus milii, the dogfish, Squalus acanthias, the goldfish, Carassius auratus, and the mouse, Mus musculus. These alignments provide the basis for phylogenetic analysis of these gnathostome melanocortin receptor sequences. In addition, the Japanese stingray melanocortin receptors were separately expressed in Chinese Hamster Ovary cells, and stimulated with stingray ACTH, α-MSH, β-MSH, γ-MSH, δ-MSH, and β-endorphin. The dose response curves reveal the order of ligand selectivity for each stingray MCR.

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