Driving Tau into Phase-separated Liquid Droplets
Tau protein, Phase separation, Alzheimer's disease, Liquid droplet
College of Natual Science and Mathematics, Chemistry and Biochemistry
Liquid–liquid phase separation of tau protein has been implicated in normal biological function as well as neurodegenerative diseases, including Alzheimer's. However, knowledge about these links is still scant, and the mechanisms driving tau into liquid droplets are poorly understood. A simplified in vitro system that uses unmodified human tau protein now suggests electrostatic interactions provide the basic instructions underlying liquid droplet formation.
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Margittai, M. (2019). Driving tau into phase-separated liquid droplets. The Journal of Biological Chemistry, 294(29), 11060-11061. DOI: 10.1074/jbc.h119.009703.