Title

Folding while Bound to Chaperones

Document Type

Article

Publication Date

7-19-2017

Keywords

Chaperones, Protein aggregation, Protein folding

Organizational Units

Knoebel Institute for Healthy Aging, Chemistry and Biochemistry

Abstract

Chaperones are important in preventing protein aggregation and aiding protein folding. How chaperones aid protein folding remains a key question in understanding their mechanism. The possibility of proteins folding while bound to chaperones was reintroduced recently with the chaperone Spy, many years after the phenomenon was first reported with the chaperones GroEL and SecB. In this review, we discuss the salient features of folding while bound in the cases for which it has been observed and speculate about its biological importance and possible occurrence in other chaperones.

Publication Statement

Copyright held by author or publisher. User is responsible for all copyright compliance.

This document is currently not available here.

Share

COinS