Title

Analysis of Shared Heritability in Common Disorders of the Brain

Authors

Verneri Anttila, Massachusetts General Hospital Harvard Medical School, Broad Institute of MIT and Harvard
Brendan Bulik-Sullivan, Massachusetts General Hospital Harvard Medical School
Hilary K. Finucane, Broad Institute of MIT and Harvard
Raymond K. Walters, Massachusetts General Hospital Harvard Medical School
Jose Bras, University College London
Laramie Duncan, Massachusetts General Hospital Harvard Medical School, Stanford University
Valentina Escott-Price, Cardiff University
Guido J. Falcone, Massachusetts General Hospital, Harvard Medical School
Padhraig Gormley, Massachusetts General Hospital Harvard Medical School, Broad Institute of MIT and Harvard
Rainer Malik, Institute for Stroke and Dementia Research (ISD), University Hospital, Munich
Nikolaos A. Patsopoulos, Broad Institute of MIT and Harvard, Brigham & Women's Hospital, Harvard Medical School
Stephan Ripke, Massachusetts General Hospital Harvard Medical School, Charite Universitatsmedizin Berlin,
Zhi Wei, New Jersey Institute of Technology
Dongmei Yu, Broad Institute of MIT and Harvard, Massachusetts General Hospital
Phil H. Lee, Broad Institute of MIT and Harvard, Massachusetts General Hospital
Patrick Turley, Massachusetts General Hospital Harvard Medical School, Broad Institute of MIT and Harvard
Benjamin Grenier-Boley, INSERM U1167 LabEx DISTALZ, Institut Pasteur de Lille,Université de Lille
Vincent Chouraki, Institut Pasteur de Lille, Université de Lille, Centre Hosp. Univ Lille
Yoichiro Kamatani, RIKEN Center for Integrative Medical Sciences, Kyoto University Graduate School of Medicine
Claudine Berr, Neuropsychiatry: Epidemiological and Clinical Research, University of Montpellier
Luc Letenneur, INSERM, University of Bordeaux
Didier Hannequin, Rouen University Hospital, Inserm U1245
Philippe Amouyel, INSERM U1167 LabEx DISTALZ, Institut Pasteur de Lille, Université de Lille
Anne Boland, Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob
Jean-François Deleuze, Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob
Emmanuelle Duron, Hôpital Broca, Hôpital Paul Brousse Université Paris Sud XI, Le Kremlin-Bicêtre
Badri N. Vardarajan, Gertrude H. Sergievsky Center and Dept of Neurology, Columbia University
Christiane Reitz, Columbia University
Alison M. Goate, Icahn School of Medicine at Mount Sinai
Matthew J. Huentelman, Translational Genomics Research Institute, Neurogenomics Division
M. Ilyas Kamboh, University of Pittsburgh
Eric B. Larson, Kaiser Permanente Washington Health Research Institute, University of Washington
Ekaterina Rogaeva, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto
Peter St George-Hyslop, University of Toronto, University of Cambridge
Hakon Hakonarson, Center for Applied Genomics of The Children's Hospital of Philadelphia, University of Pennsylvania
Walter A. Kukull, Department of Epidemiology, University of Washington
Lindsay A. Farrer, Boston University School of Medicine
Lisa L. Barnes, Rush Alzheimers Disease Center, Rush Medical College
Thomas G. Beach, Banner Sun Health Research Institute
F. Yesim Demirci, University of Pittsburgh
Elizabeth Head, Sanders-Brown Center on Aging, University of Kentucky
Christine M. Hulette, Duke University School of Medicine
Gregory A. Jicha, College of Medicine, University of Kentucky
John S.K. Kauwe, Brigham Young University
Jeffrey A. Kaye, Oregon Health & Science University
James B. Leverenz, Neurological Institute, Cleveland Clinic
Allan I. Levey, School of Medicine, Emory University
Andrew P. Lieberman, University of Michigan Medical School
Vernon S. Pankratz, University of New Mexico Health Sciences Center
Wayne W. Poon, University of California, Irvine
Joseph F. Quinn, Oregon Health and Science University, Portland Veterans Affairs Medical Center
Andrew J. Saykin, Indiana University School of Medicine
Lon S. Schneider, Keck School of Medicine of the University of Southern California
Amanda G. Smith, Byrd Alzheimer's Institute, University of South Florida
Joshua A. Sonnen, University of Utah, University of Washington
Robert A. Stern, Boston University School of Medicine
Vivianna M. Van Deerlin, Perelman School of Medicine, University of Pennsylvania
Linda J. Van Eldik, Sanders-Brown Center on Aging, University of Kentucky
Denise Harold, School of Biotechnology, Dublin City University
Giancarlo Russo, Functional Genomics Center Zurich
David C. Rubinsztein, Cambridge Institute for Medical Research, UK Dementia Research Institute
Anthony Bayer, School of Medicine, Cardiff University
Magda Tsolaki, Aristotle University of Thessaloniki, Greek Association of Alzheimer's Disease and Related Disorders
Petra Proitsi, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London
Nick C. Fox, Dementia Research Centre, UCL Institute of Neurology, University College London
Harald Hampel, Sorbonne University, Pitié-Salpêtrière Hospital, Brain & Spine Institute
Michael J. Owen, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University
Simon Mead, Institute of Prion Diseases and MRC Prion Unit, University College London
Peter Passmore, Centre for Public Health, Queens University Belfast
Kevin Morgan, University of Nottingham
Markus M. Nöthen, Life & Brain Center, University of Bonn, University of Bonn & University Hospital Bonn
Jonathan M. Schott, Dementia Research Centre, UCL Institute of Neurology
Martin Rossor, Department of Neurodegeneration, UCL Institute of Neurology
Michelle K. Lupton, QIMR Berghofer Medical Research Institute, Kings College London
Per Hoffmann, University of Bonn & University Hospital Bonn, University Hospital Basel
Johannes Kornhuber, Friedrich-Alexander-Universität Erlangen-Nürnberg University Hospital
Brian Lawlor, Department of Psychiatry and Global Brain Health Institute, Trinity College
Andrew McQuillin, Division of Psychiatry, Molecular Psychiatry Laboratory,University College London
Ammar Al-Chalabi, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London
Joshua C. Bis, Department of Medicine, University of Washington
Agustin Ruiz, Institut Català de Neurociències Aplicades, Barcelona, Universitat Internacional de Catalunya
Mercè Boada, Institut Català de Neurociències Aplicades, Barcelona, Spain and Universitat Internacional de Catalunya
Sudha Seshadri, University of Texas Health Sciences Center, Framingham Heart Study, Boston University
Alexa Beiser, Boston University, Framingham Heart Study
Kenneth Rice, Department of Biostatistics, University of Washington
Sven J. van der Lee, Department of Epidemiology, Erasmus Medical Centre, Rotterdam
Philip L. De Jager, Columbia University Medical Center
Daniel H. Geschwind, University of California, Los Angeles
Matthias Riemenschneider, Department of Psychiatry, Saarland University Hospital, Homburg
Steffi Riedel-Heller, Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig
Jerome I. Rotter, LABioMed at Harbor-UCLA Medical Center
Gerhard Ransmayr, Kepler University Clinic, Johannes Kepler University,
Bradley T. Hyman, Massachusetts General Hospital, Harvard Medical School
Carlos Cruchaga, Washington University School of Medicine in St. Louis
Montserrat Alegret, Institut Català de Neurociències Aplicades, Barcelona, Spain and Universitat Internacional de Catalunya
Bendik Winsvold, Communication and Research Unit for Musculoskeletal Disorders (FORMI), Oslo University Hospital
Priit Palta, University of Helsinki, University of Tartu
Kai-How Farh, Illumina Inc., San Diego, Broad Institute of MIT and Harvard
Ester Cuenca-Leon, Massachusetts General Hospital, Broad Institute of MIT and Harvard
Nicholas Furlotte, 23andMe Inc.
Tobias Kurth, Institute of Public Health, Charité - Universitätsmedizin Berlin
Lannie Ligthart, Vrije Universiteit Amsterdam
Gisela M. Terwindt, Leiden University Medical Center
Tobias Freilinger, Klinikum der Universitaet Muenchen, University of Tuebingen
Caroline Ran, Department of Neuroscience, Karolinska Institutet
Scott D. Gordon, QIMR Berghofer Medical Research Institute
Guntram Borck, Institute of Human Genetics, University of Ulm
Hieab H.H. Adams, Erasmus Medical Centre, Rotterdam
Terho Lehtimäki, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere
Juho Wedenoja, University of Helsinki and Helsinki University Hospital
Julie E. Buring, Brigham and Women's Hospital, Boston
Markus Schürks, Department of Neurology, University Hospital Essen, Germany.
Maria Hrafnsdottir, Landspitali National University Hospital, Reykjavik
Jouke-Jan Hottenga, Vrije Universiteit Amsterdam, Avera Institute for Human Genetics, Sioux Falls
Brenda Penninx, VU University Medical Center, Amsterdam
Ville Artto, Helsinki University Central Hospital
Mari Kaunisto, Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
Salli Vepsäläinen, Helsinki University Central Hospital
Nicholas G. Martin, QIMR Berghofer Medical Research Institute, Brisbane
Grant W. Montgomery, QIMR Berghofer Medical Research Institute, Brisbane, University of Queensland
Mitja I. Kurki, Massachusetts General Hospital Harvard Medical School, University of Helsinki
Eija Hämäläinen, Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
Hailiang Huang, Massachusetts General Hospital Harvard Medical School, Broad Institute of MIT and Harvard, Harvard Medical School
Jie Huang, Boston VA Research Institute, Brigham Women's Hospital Division of Aging, Harvard Medical School
Cynthia Sandor, Department of Physiology, Anatomy and Genetics, University of Oxford
Caleb Webber, Department of Physiology, Anatomy and Genetics, University of Oxford, Cardiff University,
Bertram Muller-Myhsok, Max Planck Institute of Psychiatry, Munich,Munich Cluster for Systems Neurology, University of Liverpool
Stefan Schreiber, Institute of Clinical Molecular Biology, Kiel University and University Hospital Schleswig-Holstein
Veikko Salomaa, National Institute for Health and Welfare, Helsinki
Elizabeth Loehrer, Department of Environmental Health, Harvard T.H. Chan School of Public Health
Hartmut Göbel, Kiel Pain and Headache Center
Alfons Macaya, Vall d'Hebron Research Institute, Autonomous University of Barcelona
Patricia Pozo-Rosich, Hospital Vall d'Hebron, Barcelona, Autonomous University of Barcelona
Thomas Hansen, Rigshospitalet Glostrup and University of Copenhagen, Institute of Biological Psychiatry
Thomas Werge, Institute of Biological Psychiatry, University of Copenhagen, iPSYCH, Aarhus
Jaakko Kaprio, HiLIFE, University of Helsinki, Department of Public Health, University of Helsinki,
Andres Metspalu, Estonian Genome Center, Institute of Genomics, University of Tartu
Christian Kubisch, University Medical Center Hamburg-Eppendorf
Michel D. Ferrari, Leiden University Medical Center
Andrea C. Belin, Department of Neuroscience, Karolinska Institutet, Stockholm
Arn M.J.M. van den Maagdenberg, Leiden University Medical Center
John-Anker Zwart, Oslo University Hospital and University of Oslo
Dorret Boomsma, Netherlands Twin Register, Vrije Universiteit, Amsterdam
Nicholas Eriksson, 23andMe Inc.
Jes Olesen, Rigshospitalet Glostrup and University of Copenhagen
Daniel I. Chasman, Brigham and Women's Hospital, Boston
Dale R. Nyholt, Institute of Health and Biomedical Innovation, Queensland University of Technology
Richard Anney, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, School of Medicine, Cardiff University
Andreja Avbersek, Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology
Larry Baum, Centre for Genomic Sciences, University of Hong Kong
Samuel Berkovic, Epilepsy Research Centre, University of Melbourne
Jonathan Bradfield, Quantinuum Research LLC, San Diego
Russell Buono, Cooper Medical School of Rowan University, Thomas Jefferson University Hospital, Children's Hospital of Philadelphia
Claudia B. Catarino, Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Epilepsy Society, Chalfont-St-Peter,
Patrick Cossette, Centre de Recherche du Centre Hospitalier de l'Universite de Montreal and Department of Neurosciences, Université de Montréal
Peter De Jonghe, Neurogenetics Group, VIB-CMN, University of Antwerp, Antwerp University Hospital
Chantal Depondt, Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles
Dennis Dlugos, Children's Hospital of Philadelphia,Perelman School of Medicine at the University of Pennsylvania
Thomas N. Ferraro, Cooper Medical School of Rowan University, Perelman School of Medicine at the University of Pennsylvania
Jacqueline French, NYU School of Medicine
Helle Hjalgrim, Amplexa Genetics A/S, Odense, Denmark
Jennifer Jamnadas-Khoda, UCL Institute of Neurology, London, University of Nottingham
Reetta Kälviäinen, Kuopio University Hospital, University of Eastern Finland
Wolfram S. Kunz, University Bonn Medical Center, Institute of Experimental Epileptology and Cognition Research
Holger Lerche, Hertie Institute for Clinical Brain Research, University of Tuebingen
Costin Leu, NIHR University College London Hospitals Biomedical Research Centre, UCL Institute of Neurology
Dick Lindhout, University Medical Center Utrecht, Epilepsy Foundation in the Netherlands
Warren Lo, Ohio State University, Nationwide Children's Hospital
Daniel Lowenstein, Department of Neurology, University of California
Mark McCormack, Royal College of Surgeons in Ireland, University Medical Center Utrecht
Rikke S. Møller, Danish Epilepsy Centre, University of Southern Denmark
Anne Molloy, Trinity College Dublin
Ping-Wing Ng, United Christian Hospital, Hong Kong Sanatorium and Hospital
Karen Oliver, Epilepsy Research Centre, University of Melbourne
Michael Privitera, University of Cincinnati, UC Gardner Neuroscience Institute
Rodney Radtke, Duke University School of Medicine
Ann-Kathrin Ruppert, Cologne Center for Genomics (CCG), University of Cologne
Thomas Sander, Cologne Center for Genomics (CCG), University of Cologne
Steven Schachter, Beth Israel Deaconess Medical Center, Massachusetts General Hospital
Christoph Schankin, Bern University Hospital, University of Bern, University of Munich Hospital
Ingrid Scheffer, The University of Melbourne, Royal Children's Hospital
Susanne Schoch, Institute of Neuropathology, Bonn University Medical School
Sanjay M. Sisodiya, UCL Institute of Neurology, Chalfont Centre for Epilepsy
Philip Smith, University Hospital of Wales
Michael Sperling, Thomas Jefferson University, Philadelphia
Pasquale Striano, Pediatric Neurology and Muscular Diseases Unit-Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health University of Genoa
Rainer Surges, University Hospital Bonn, University Hospital RWTH Aachen
G. Neil Thomas, Institute of Applied Health Research, University of Birmingham
Frank Visscher, Admiraal De Ruyter Hospital, Goes, The Netherlands
Christopher D. Whelan, Royal College of Surgeons in Ireland, Dublin, Ireland
Federico Zara, Laboratory of Neurogenetics, G. Gaslini Institute
Erin L. Heinzen, Institute for Genomic Medicine, Columbia University Medical Center
Anthony Marson, University of Liverpool, Walton Centre NHS Foundation Trust
Felicitas Becker, University Hospital Tuebingen, University of Ulm
Hans Stroink, CWZ Hospital, Nijmegen, Netherlands.
Fritz Zimprich, Medical University of Vienna
Thomas Gasser, University of Tübingen, German Center for Neurodegenerative Diseases
Raphael Gibbs, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
Peter Heutink, German Center for Neurodegenerative Diseases (DZNE), Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
Maria Martinez, INSERM U1220, Université Paul Sabatier, Toulouse, France
Huw R. Morris, UCL Institute of Neurology, London
Manu Sharma, Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometery, University of Tubingen
Mina Ryten, UCL Institute of Neurology, London
Kin Y. Mok, Institute of Neurology, University College London, Hong Kong University of Science and Technology,
Sara Pulit, University Medical Center Utrecht, Li Ka Shing Centre for Health Information and Discovery, University of Oxford
Steve Bevan, University of Lincoln, Lincoln, UK
Elizabeth Holliday, Faculty of Health and Medicine, University of Newcastle
John Attia, University of Newcastle, Callaghan, Australia, Hunter Medical Research Institute, Newcastle, Australia
Thomas Battey, Massachusetts General Hospital
Giorgio Boncoraglio, Fondazione IRCCS Istituto Neurologico Carlo Besta, University Milano-Bicocca
Vincent Thijs, Florey Institute of Neuroscience and Mental Health,Austin Health, Heidelberg, Australia
Wei-Min Chen, University of Virginia Center for Public Health Genomics, University of Virginia
Braxton Mitchell, University of Maryland School of Medicine,Baltimore Veterans Administration Medical Center
Peter Rothwell, Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford
Pankaj Sharma, Institute of Cardiovascular Research, Royal Holloway University of London,Ashford & St Peters NHS Foundation Trust
Cathie Sudlow, University of Edinburgh
Astrid Vicente, Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisboa, Portugal, BioISI, University of Lisboa
Hugh Markus, Department of Clinical Neurosciences, University of Cambridge
Christina Kourkoulis, Broad Institute of MIT and Harvard, Massachusetts General Hospital
Joana Pera, Jagiellonian University Medical College, Kraków, Poland
Miriam Raffeld, Broad Institute of MIT and Harvard, Massachusetts General Hospital,The Warren Alpert Medical School of Brown University
Scott Silliman, College of Medicine-Jacksonville, University of Florida
Vesna Boraska Perica, University of Split School of Medicine, Split, Croatia
Laura M. Thornton, University of North Carolina at Chapel Hill
Laura M. Huckins, Icahn School of Medicine at Mount Sinai
N. William Rayner, University of Oxford, Wellcome Sanger Institute
Cathryn M. Lewis, MRC Social, Genetic and Developmental Psychiatry Centre, King's College London
Monica Gratacos, Genes and Disease Programme, Centre for Genomic Regulation (CRG), Barcelona
Filip Rybakowski, Department of Adult Psychiatry, Poznan University of Medical Sciences
Anna Keski-Rahkonen, Clinicum, Department of Public Health, University of Helsinki
Anu Raevuori, Helsinki University Central Hospital,Clinicum, Department of Public Health, University of Helsinki
James I. Hudson, Harvard Medical School/McLean Hospital
Ted Reichborn-Kjennerud, Norwegian Institute of Public Health, University of Oslo
Palmiero Monteleone, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno
Andreas Karwautz, Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna
Katrin Mannik, Estonian Genome Center, Institute of Genomics, University of Tartu,Center for Integrative Genomics, University of Lausanne
Jessica H. Baker, University of North Carolina at Chapel Hill
Julie K. O’Toole, Kartini Clinic, Portland
Sara E. Trace, Department of Psychiatry, University of North Carolina at Chapel Hill
Oliver S. P. Davis, MRC Integrative Epidemiology Unit and Bristol Medical School, University of Bristol
Sietske G. Helder, Zorg op Orde BV, Leidschendam, The Netherlands, MRC Social, Genetic and Developmental Psychiatry Centre, King's College London
Stefan Ehrlich, Division of Psychological & Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technischen Universität Dresden
Beate Herpertz-Dahlmann, Department of Child & Adolescent Psychiatry & Psychosomatic Medicine of University Clinics, RWTH Aachen
Unna N. Danner, Altrecht Eating Disorders Rintveld, University of Utrecht Altrecht Mental Health Institute,
Annemarie A. van Elburg, Altrecht Eating Disorders Rintveld, Altrecht Mental Health Institute, University of Utrecht,
Maurizio Clementi, Medical Genetics Unit, Department SDB, University of Padova
Monica Forzan, UOC Genetica ed Epidemiologica Clinica Az. Ospedaliera, Padova
Elisa Docampo, CHU Sart-Tilman, University of Liège
Jolanta Lissowska, Cancer Center and M. Sklodowska-Curie Institute of Oncology, Warsaw, Poland
Joanna Hauser, University of Medical Sciences, Poznan, Poland
Alfonso Tortorella, University of Perugia
Mario Maj, University of Campania
Fragiskos Gonidakis, National and Kapodistrian University of Athens
Konstantinos Tziouvas, Aglaia Kyriakou Childrens Hospital
Hana Papezova, Charles University, General University Hospital, Prague
Zeynep Yilmaz, University of North Carolina at Chapel Hill
Gudrun Wagner, Medical University of Vienna
Sarah Cohen-Woods, Flinders University
Stefan Herms, University of Bonn & University Hospital Bonn, University Hospital Basel
Antonio Julià, Vall d'Hebron Research Institute, Barcelona
Raquel Rabionet, Institut de Recerca Sant Joan de Déu, University of Barcelona, Centre for Genomic Regulation
Danielle M. Dick, Virginia Commonwealth University
Samuli Ripatti, University of Helsinki, Broad Institute of MIT and Harvard
Ole A. Andreassen, University of Oslo, Oslo University Hospital
Thomas Espeseth, University of Oslo, University of Bergen
Astri J. Lundervold, University of Bergen
Vidar M. Steen, University of Bergen, Haukeland University Hospital
Dalila Pinto, Icahn School of Medicine at Mount Sinai
Stephen W. Scherer, University of Toronto, The Centre for Applied Genomics, Hospital for Sick Children
Harald Aschauer, Biopsychosocial Corporation, Vienna
Alexandra Schosser, Medical University of Vienna, Zentren für Seelische Gesundheit, BBRZ-Med
Lars Alfredsson, Institute of Environmental Medicine, Karolinska Institutet
Leonid Padyukov, Karolinska Institutet and Karolinska University Hospital
Katherine A. Halmi, Weill Cornell Medical College
James Mitchell, University of North Dakota, Neuropsychiatric Research Institute
Michael Strober, University of California at Los Angeles
Andrew W. Bergen, BioRealm, Walnut, California, Oregon Research Institute
Walter Kaye, University of California San Diego
Jin Peng Szatkiewicz, University of North Carolina at Chapel Hill
Bru Cormand, Institut de Recerca Sant Joan de Déu, Barcelona, University of Barcelona, Instituto de Salud Carlos III,
Josep Antoni Ramos-Quiroga, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Instituto de Salud Carlos III
Cristina Sánchez-Mora, Universitat Autònoma de Barcelona, Instituto de Salud Carlos III
Marta Ribasés, Universitat Autònoma de Barcelona, Instituto de Salud Carlos III, Hospital Universitari Vall d'Hebron
Miguel Casas, Universitat Autònoma de Barcelona, Hospital Universitari Vall d'Hebron, Clinica Galatea y PAIMM
Amaia Hervas, Hospital Universitario Mútua de Terrassa
Maria Jesús Arranz, Fundació Docència i Recerca Mútua Terrassa
Jan Haavik, University of Bergen, Haukeland University Hospital
Tetyana Zayats, University of Bergen, Massachusetts General Hospital Harvard Medical School
Stefan Johansson, University of Bergen, Haukeland University Hospital
Nigel Williams, Cardiff University
Josephine Elia, Nemours A.I. duPont Hospital for Children, Sidney Kimmel Medical College, Thomas Jefferson University
Astrid Dempfle, Institute of Medical Informatics and Statistics, Kiel University
Aribert Rothenberger, University Medical Center, Goettingen
Jonna Kuntsi, Institute of Psychiatry, Psychology and Neuroscience, King's College London
Robert D. Oades, University of Duisburg-Essen
Tobias Banaschewski, University of Heidelberg
Barbara Franke, Radboud University Medical Center, Radboud University
Jan K. Buitelaar, Radboud University Medical Centre, Karakter Child and Adolescent Psychiatry University Center
Alejandro Arias Vasquez, Radboud University Medical Center
Alysa E. Doyle, Massachusetts General Hospital, Harvard Medical School
Andreas Reif, University Hospital Frankfurt
Klaus-Peter Lesch, I.M. Sechenov First Moscow State Medical University, Maastricht University
Christine Freitag, University Hospital Frankfurt, Goethe University
Olga Rivero, University of Wuerzburg
Haukur Palmason, Landspitali National University Hospital
Marcel Romanos, University Hospital of Wuerzburg
Kate Langley, Cardiff University
Marcella Rietschel, University of Heidelberg
Stephanie H. Witt, University of Heidelberg
Soeren Dalsgaard, Aarhus University, Hospital of Telemark
Anders D. Børglum, Aarhus University, Aarhus Genome Center
Irwin Waldman, Emory University
Beth Wilmot, Oregon Health & Science University
Nikolas Molly, University of Iowa
Claiton H.D. Bau, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre
Jennifer Crosbie, Research Institute, Hospital for Sick Children, Toronto, University of Toronto
Russell Schachar, University of Toronto, Hospital for Sick Children, Toronto
Sandra K. Loo, University of California, Los Angeles
James J. McGough, University of California at Los Angeles
Eugenio H. Grevet, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul
Sarah E. Medland, QIMR Berghofer Medical Research Institute, Brisbane
Elise Robinson, Massachusetts General Hospital Harvard Medical School, Broad Institute of MIT and Harvard, Harvard T.H. Chan School of Public Health
Lauren A. Weiss, University of California, San Francisco, Weill Institute for Neurosciences
Elena Bacchelli, University of Bologna
Anthony Bailey, University of British Columbia
Vanessa Bal, University of California, San Francisco
Agatino Battaglia, Stella Maris Clinical Research Institute for Child and Adolescent Neuropsychiatry, Pisa
Catalina Betancur, Institut de Biologie Paris Seine
Patrick Bolton, Institute of Psychiatry, Psychology and Neuroscience, King's College London, NIHR Biomedical Research Centre in Mental Health Maudsley Hospital
Rita Cantor, David Geffen School of Medicine, University of California at Los Angeles
Patrícia Celestino-Soper, LifeOmic, Indianapolis
Geraldine Dawson, Duke University
Silvia De Rubeis, Icahn School of Medicine at Mount Sinai
Frederico Duque, Centro Hospitalar e Universitário de Coimbra, University of Coimbra
Andrew Green, Our Lady's Children's Hospital, Crumlin, Dublin, University College Dublin
Sabine M. Klauck, German Cancer Research Center (DKFZ), Heidelberg
Marion Leboyer, nserm U955, Psychiatrie Translationnelle, Université Paris Est
Pat Levitt, Children's Hospital Los Angeles, Keck School of Medicine of the University of Southern California
Elena Maestrini, University of Bologna
Shrikant Mane, Yale Center for Genome Analysis, Yale University, Yale University School of Medicine
Daniel Moreno- De-Luca, Brown University
Jeremy Parr, Newcastle University, Newcastle Upon Tyne Hospitals NHS Foundation Trust
Regina Regan, University College Dublin, Genomics Medicine Ireland
Abraham Reichenberg, Icahn School of Medicine at Mount Sinai
Sven Sandin, Icahn School of Medicine at Mount Sinai, Karolinska Institutet, Stockholm
Jacob Vorstman, Hospital for Sick Children and University of Toronto
Thomas Wassink, Carver College of Medicine, University of Iowa
Ellen Wijsman, University of Washington
Edwin Cook, University of Illinois at Chicago
Susan Santangelo, Maine Medical Center Research Institute, Tufts University School of Medicine
Richard Delorme, Robert Debre Hospital, APHP, Paris, Institut Pasteur
Bernadette Rogé, Université Toulouse Jean Jaurès, CERESA, Institut Universitaire de France,
Tiago Magalhaes, Genomics Medicine Ireland, Academic Centre on Rare Diseases University College Dublin
Dan Arking, Johns Hopkins University School of Medicine
Thomas G. Schulze, Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University Medical Center Göttingen,
Robert C. Thompson, Molecular and Behavioral Neuroscience Institute, University of Michigan
Jana Strohmaier, University of Heidelberg, SRH University Heidelberg
Keith Matthews, University of Dundee, Advanced Interventions Service, NHS Tayside
Ingrid Melle, University of Oslo, Oslo University Hospital
Derek Morris, National University of Ireland Galway
Douglas Blackwood, University of Edinburgh
Andrew McIntosh, University of Edinburgh
Sarah E. Bergen, Karolinska Institutet, Stockholm
Martin Schalling, Karolinska Institutet, Karolinska University Hospital
Stéphane Jamain, Inserm U955, Psychiatrie Translationnelle, Université Paris Est, Fondation FondaMental
Anna Maaser, University of Bonn & University Hospital Bonn
Sascha B. Fischer, University of Basel, University Hospital Basel
Céline S. Reinbold, University of Basel, University Hospital Basel
Janice M. Fullerton, Neuroscience Research Australia, University of New South Wales
Maria Grigoroiu-Serbanescu, Alexandru Obregia Clinical Psychiatric Hospital, Biometric Psychiatric Genetics Research Unit
José Guzman-Parra, Hospital Regional Universitario de Malaga, Instituto de Investigación Biomédica de Málaga
Fermin Mayoral, Hospital Regional Universitario de Malaga, Instituto de Investigación Biomédica de Málaga
Peter R. Schofield, Neuroscience Research Australia, University of New South Wales
Sven Cichon, University Hospital Basel, University of Basel, Research Centre Jülich
Thomas W. Mühleisen, Research Centre Jülich, University of Basel
Franziska Degenhardt, Institute of Human Genetics, University of Bonn
Johannes Schumacher, Institute of Human Genetics, University of Bonn
Michael Bauer, University Hospital Carl Gustav Carus, Technische Universität Dresden
Philip B. Mitchell, University of New South Wales, Black Dog Institute
Elliot S. Gershon, University of Chicago
John Rice, Washington University, St. Louis
James B. Potash, Johns Hopkins University
Peter P. Zandi, Johns Hopkins Bloomberg School of Public Health
Nick Craddock, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University
I. Nicol Ferrier, Institute of Neuroscience, Newcastle University
Martin Alda, Dalhousie University, Halifax, National Institute of Mental Health, Klecany
Guy A. Rouleau, Montreal Neurological Institute, McGill University
Gustavo Turecki, McGill University
Roel Ophoff, University of California at Los Angeles, UMC Utrecht
Carlos Pato, SUNY Downstate Medical Center
Adebayo Anjorin, University College London
Eli Stahl, Icahn School of Medicine at Mount Sinai, Broad Institute of MIT and Harvard,
Markus Leber, Hospital for Psychiatry and Psychotherapy, Cologne
Piotr M. Czerski, Poznan University of Medical Sciences
Howard J. Edenberg, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine
Cristiana Cruceanu, Douglas Mental Health University Institute, McGill University, Max-Planck Institute of Psychiatry, Munich
Ian R. Jones, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University
Danielle Posthuma, Center for Neurogenomics and Cognitive Research, VU University, Amsterdam
Till F.M. Andlauer, Max Planck Institute of Psychiatry, Munich, Technical University of Munich
Andreas J. Forstner, University of Bonn & University Hospital Bonn, University Hospital Basel, University of Basel
Fabian Streit, University of Heidelberg, Mannheim
Bernhard T. Baune, Discipline of Psychiatry, University of Adelaide
Tracy Air, Discipline of Psychiatry, University of Adelaide
Grant Sinnamon, James Cook University, Bond University, Faculty of Society and Design, Robina
Naomi R. Wray, University of Queensland, Technical University of Munich
Donald J. MacIntyre, Centre for Clinical Brain Sciences, University of Edinburgh
David Porteous, Centre for Genomic and Experimental Medicine, University of Edinburgh
Georg Homuth, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
Margarita Rivera, Center for Biomedical Research, University of Granada, King's College London
Jakob Grove, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus University
Christel M. Middeldorp, University of Queensland, Children's Health Queensland Health and Hospital Service
Ian Hickie, Brain and Mind Centre, University of Sydney
Michele Pergadia, Washington University School of Medicine in St. Louis
Divya Mehta, Queensland University of Technology, University of Queensland
Johannes H. Smit, VU University Medical Center, GGZ Ingeest, Specialized Mental Health Care, Amsterdam
Rick Jansen, VU University Medical Center, Amsterdam
Eco de Geus, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute
Erin Dunn, Harvard Medical School, Massachusetts General Hospital
Qingqin S. Li, Janssen Research & Development LLC
Matthias Nauck, University Medicine Greifswald, German Centre for Cardiovascular Research
Robert A. Schoevers, University Medical Center Groningen, University of Groningen
Aartjan TF Beekman, VU University Medical Center, Department of Psychiatry GGZ INGEEST
James A. Knowles, SUNY Downstate Medical Center
Alexander Viktorin, Karolinska Institutet, Stockholm
Paul Arnold, Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary
Cathy L. Barr, Hospital for Sick Children, University of Toronto, Krembil Research Institute, University Health Network
Gabriel Bedoya-Berrio, Universidad de Antioquia, Medellín, Colombia
O. Joseph Bienvenu, Johns Hopkins University School of Medicine
Helena Brentani, Sao Paulo Medical School, University of Sao Paulo
Christie Burton, Hospital for Sick Children, Toronto
Beatriz Camarena, Instituto Nacional de Psiquiatria Ramon de la Fuente Muñiz, Mexico City
Carolina Cappi, Sao Paulo Medical School, University of Sao Paulo
Danielle Cath, University of Groningen and University Medical Center, GGZ Drenthe Mental Health Care Services
Maria Cavallini, Ospedale San Raffaele, Milano
Daniele Cusi, Bio4Dreams Srl, Milan
Sabrina Darrow, University of California, San Francisco
Damiaan Denys, Academic Medical Center, University of Amsterdam, Netherlands Institute for Neuroscience
Eske M. Derks, QIMR Berghofer Medical Research Institute
Andrea Dietrich, University of Groningen, University Medical Center Groningen
Thomas Fernandez, Yale University School of Medicine
Martijn Figee, Academic Medical Center, University of Amsterdam,Icahn School of Medicine at Mount Sinai
Nelson Freimer, Semel Institute for Neuroscience & Human Behavior, University of California at Los Angeles
Gloria Gerber, Center for Genomic Medicine, Massachusetts General Hospital
Marco Grados, Johns Hopkins University
Erica Greenberg, Massachusetts General Hospital
Gregory L. Hanna, Department of Psychiatry, University of Michigan
Andreas Hartmann, Groupe Hospitalier Pitié-Salpêtrière, Paris, Sorbonne Universités
Matthew E. Hirschtritt, University of California, San Francisco, Weill Institute for Neurosciences
Pieter J. Hoekstra, University Medical Center Groningen
Alden Huang, Bioinformatics Interdepartmental Program, University of California, Semel Institute for Neuroscience & Human Behavior
Chaim Huyser, De Bascule, Amsterdam, Academic Medical Center, University of Amsterdam
Cornelia Illmann, Massachusetts General Hospital
Michael Jenike, Harvard Medical School
Samuel Kuperman, Carver College of Medicine, University of Iowa
Bennett Leventhal, University of California, San Francisco
Christine Lochner, MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, University of Cape Town
Gholson J. Lyon, Cold Spring Harbor Laboratory
Fabio Macciardi, Department of Psychiatry and Human Behavior, University of California
Marcos Madruga-Garrido, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla
Irene A. Malaty, Department of Neurology, University of Florida
Athanasios Maras, Yulius Academy, Yulius Mental Health Organization, Barendrecht
Lauren M. McGrath, University of DenverFollow
Eurípedes C. Miguel, Faculdade de Medicina FMUSP, Universidade de São Paulo
Pablo Mir, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla
Gerald Nestadt, Johns Hopkins University
Humberto Nicolini, National Institute of Genomic Medicine, Clinical Research, Grupo Médico Carracci,
Michael S. Okun, Departments of Neurology and Neurosurgery, University of Florida, Fixel Center for Neurological Diseases
Andrew Pakstis, Yale University School of Medicine
Peristera Paschou, Department of Biological Sciences, Purdue University
John Piacentini, Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, University of California at Los Angeles
Christopher Pittenger, Department of Psychiatry, Yale School of Medicine
Kerstin Plessen, Lausanne University Hospital, Mental Health Services Capital Region Copenhagen, University of Copenhagen
Vasily Ramensky, Moscow Institute of Physics and Technology
Eliana M. Ramos, David Geffen School of Medicine, University of California at Los Angeles
Victor Reus, University of California, San Francisco, Weill Institute for Neurosciences
Margaret A. Richter, Frederick W. Thompson Anxiety Disorders Centre, Sunnybrook Health Sciences Centre, University of Toronto
Mark A. Riddle, Johns Hopkins University School of Medicine
Mary M. Robertson, University College London
Veit Roessner, Technischen Universität Dresden
Maria Rosário, Federal University of São Paulo, Yale Child Study Center, Yale University School of Medicine
Jack F. Samuels, Johns Hopkins University
Paul Sandor, University of Toronto, University Health Network, Youthdale Treatment Centers
Dan J. Stein, Groote Schuur Hospital, Cape Town, University of Cape Town
Fotis Tsetsos, Department of Molecular Biology and Genetics, Democritus University of Thrace
Filip Van Nieuwerburgh, Laboratory of Pharmaceutical Biotechnology, Ghent University
Sarah Weatherall, Massachusetts General Hospital
Jens R. Wendland, Pfizer, Inc.
Tomasz Wolanczyk, Department of Child Psychiatry, Medical University of Warsaw
Yulia Worbe, Sorbonne Université, Pitie-Salpetriere Hospital, Saint Antoine Hospital
Gwyneth Zai, University of Toronto
Fernando S. Goes, Johns Hopkins University
Nicole McLaughlin, Butler Hospital, Alpert Medical School of Brown University
Paul S. Nestadt, Johns Hopkins University
Hans-Jorgen Grabe, University Medicine Greifswald
Christel Depienne, University Hospital Essen, University Duisburg-Essen, IGBMC, CNRS UMR 7104/INSERM U964/Université de Strasbourg
Anuar Konkashbaev, Vanderbilt University Medical Center
Nuria Lanzagorta, Clinical Research, Grupo Médico Carracci
Ana Valencia-Duarte, Universidad Pontificia Bolivariana, Universidad de Antioquia,
Elvira Bramon, Molecular Psychiatry Laboratory,University College London
Nancy Buccola, Louisiana State University Health Sciences Center
Wiepke Cahn, University Medical Center Utrecht
Murray Cairns, The University of Newcastle, Hunter Medical Research Institute, Schizophrenia Research Institute
Siow A. Chong, Institute of Mental Health, Singapore
David Cohen, GH Pitié-Salpêtrière, Sorbonne Université, CNRS UMR 7222 Institut des Systèmes Intelligents et Robotiques
Benedicto Crespo-Facorro, University Hospital Marqués de Valdecilla, Santander, Instituto de Salud Carlos III
James Crowley, University of North Carolina at Chapel Hill
Michael Davidson, Minerva Neurosciences Inc., Sackler School of Medicine, Tel Aviv University
Lynn DeLisi, VA Boston Healthcare System, Harvard Medical School
Timothy Dinan, APC Microbiome Ireland, University College Cork
Gary Donohoe, National University of Ireland Galway
Elodie Drapeau, Icahn School of Medicine at Mount Sinai
Jubao Duan, NorthShore University HealthSystem Research Institute, University of Chicago
Lieuwe Haan, Academic Medical Center, University of Amsterdam, Arkin, Amsterdam
David Hougaard, Statens Serum Institut, Copenhagen
Sena Karachanak-Yankova, Medical University, Sofia, Bulgaria
Andrey Khrunin, Institute of Molecular Genetics, Russian Academy of Sciences
Janis Klovins, Latvian Biomedical Research and Study Centre, Riga
Vaidutis Kučinskas, Vilnius University, Vilnius, Lithuania
Jimmy Lee Chee Keong, Lee Kong Chian School of Medicine, Nanyang Technological University
Svetlana Limborska, Institute of Molecular Genetics, Russian Academy of Sciences
Carmel Loughland, Hunter New England Local Health District, Newcastle, Australia, University of Newcastle
Jouko Lönnqvist, National Institute for Health and Welfare, University of Helsinki
Brion Maher, Johns Hopkins Bloomberg School of Public Health
Manuel Mattheisen, Center of Mental Health, University Hospital Wuerzburg, Aarhus University, Karolinska Institute
Colm McDonald, Centre for Neuroimaging and Cognitive Genomics, National University of Ireland
Kieran C. Murphy, Royal College of Surgeons in Ireland
Robin Murray, Institute of Psychiatry, Psychology and Neuroscience, King's College London
Igor Nenadic, Philipps-Universität Marburg and Marburg University Hospital UKGM, Jena University Hospital
Jim van Os, University Medical Center Utrecht, Maastricht University Medical Centre, King's College London
Christos Pantelis, University of Melbourne & Melbourne Health, Florey Institute of Neuroscience and Mental Health, Melbourne
Michele Pato, SUNY Downstate Medical Center
Tracey Petryshen, Broad Institute of MIT and Harvard, Massachusetts General Hospital
Digby Quested, Oxford Health NHS Foundation Trust, University of Oxford
Panos Roussos, Icahn School of Medicine at Mount Sinai
Alan R. Sanders, NorthShore University HealthSystem Research Institute, University of Chicago
Ulrich Schall, University of Newcastle - Australia
Sibylle G. Schwab, Faculty of Science, Medicine and Health, University of Wollongong
Kang Sim, Yong Loo Lin School of Medicine, National University of Singapore, Lee Kong Chian School of Medicine, Nanyang Technological University,
Hon-Cheong So, Chinese University of Hong Kong, Kunming Institute of Zoology, Chinese Academy of Sciences
Elisabeth Stögmann, Medical University of Vienna
Mythily Subramaniam, Institute of Mental Health, Singapore, Nanyang Technological University
Draga Toncheva, Department of Medical Genetics, Medical University, Sofia, Bulgaria
John Waddington, Royal College of Surgeons in Ireland
James Walters, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University,
Mark Weiser, Sackler School of Medicine, Tel Aviv University, Sheba Medical Center, Ramat Gan, Israel.
Wei Cheng, University of North Carolina at Chapel Hill
Robert Cloninger, Washington University School of Medicine in St. Louis
David Curtis, UCL Genetics Institute, University College London, Barts and the London School of Medicine and Dentistry
Pablo V. Gejman, University of Chicago, NorthShore University HealthSystem Research Institute
Frans Henskens, School of Medicine & Public Health, University of Newcastle, Priority Research Centre for Health Behaviour, University of Newcastle
Morten Mattingsdal, Institute of Clinical Medicine, University of Oslo, Sørlandet Hospital
Sang-Yun Oh, University of California, Santa Barbara, Lawrence Berkeley National Laboratory, University of California at Berkeley
Rodney Scott, University of Newcastle, Hunter Medical Research Institute, NSW Health Pathology
Bradley Webb, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University
Gerome Breen, Institute of Psychiatry, Psychology & Neuroscience, Social Genetics & Developmental Psychiatry Center, MRC, Kings College London, NIHR Maudsley Biomedical Research Centre
Claire Churchhouse, Massachusetts General Hospital Harvard Medical School, Broad Institute of MIT and Harvard
Cynthia M. Bulik, University of North Carolina at Chapel Hill, Karolinska Institutet
Mark Daly, Massachusetts General Hospital Harvard Medical School, Broad Institute of MIT and Harvard
Martin Dichgans, University Hospital, LMU Munich, Munich Cluster for Systems Neurology (SyNergy)
Stephen V. Faraone, SUNY Upstate Medical University
Rita Guerreiro, UK Dementia Research Institute, University College London, Institute of Neurology, University College London
Peter Holmans, Cardiff University, Medical Research Council Center for Neuropsychiatric Genetics & Genomics, Institute of Psychology, Medicine & Clinical Neuroscience
Kenneth S. Kendler, Virginia Commonwealth University
Bobby Koeleman, University Medical Center Utrecht
Carol A. Mathews, Department of Psychiatry and UF Genetics Institute, University of Florida, McKnight Brain Institute, University of Florida
Alkes Price, Broad Institute of MIT and Harvard, Harvard T.H. Chan School of Public Health
Jeremiah Scharf, Broad Institute of MIT and Harvard, Massachusetts General Hospital, Brigham and Women's Hospital
Pamela Sklar, Icahn School of Medicine at Mount Sinai
Julie Williams, Cardiff University, Dementia Research Institute
Nicholas W. Wood, Institute of Neurology, University College London, UCL Genetics Institute, University College London
Chris Cotsapas, Broad Institute of MIT and Harvard, Yale School of Medicine
Aarno Palotie, Massachusetts General Hospital Harvard Medical School, Broad Institute of MIT and Harvard, Massachusetts General Hospital,
Jordan W. Smoller, Broad Institute of MIT and Harvard, Massachusetts General Hospital
Patrick Sullivan, University of North Carolina at Chapel Hill, University of North Carolina School of Medicine
Jonathan Rosand, Broad Institute of MIT and Harvard, Massachusetts General Hospital, Harvard Medical School
Aiden Corvin, Broad Institute of MIT and Harvard, Trinity College Dublin
Benjamin M. Neale, Massachusetts General Hospital Harvard Medical School, Broad Institute of MIT and Harvard

Document Type

Article

Publication Date

6-21-2018

Organizational Units

College of Arts Humanities and Social Sciences, Psychology

Abstract

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.

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