Title

5-HTTLPR×interpersonal Stress Interaction and Nonsuicidal Self-injury in General Community Sample of Youth

Document Type

Article

Publication Date

2-2015

Organizational Units

College of Arts Humanities and Social Sciences, Psychology

Abstract

No research with youth has investigated whether measured genetic risk interacts with stressful environment (G⁎E) to explain engagement in non-suicidal self-injury (NSSI). Two independent samples of youth were used to test the a priori hypothesis that the Transporter-Linked Polymorphic Region (5-HTTLPR) would interact with chronic interpersonal stress to predict NSSI. We tested this hypothesis with children and adolescents from United States public schools in two independent samples (N׳s=300 and 271) using identical procedures and methods. They were interviewed in person with the Self-Injurious Thoughts and Behaviors Interview to assess NSSI engagement and with the UCLA Chronic Stress Interview to assess interpersonal stress. Buccal cells were collected for genotyping of 5-HTTLPR. For both samples, ANOVAs revealed the hypothesized G⁎E. Specifically, short carriers who experienced severe interpersonal stress exhibited the highest level of NSSI engagement. Replicated across two independent samples, results provide the first demonstration that youth at high genetic susceptibility (5-HTTLPR) and high environmental exposure (chronic interpersonal stress) are at heightened risk for NSSI.

Compass Link

https://du-primo.hosted.exlibrisgroup.com/permalink/f/1jii0mc/TN_cdi_proquest_miscellaneous_1652437495

Publication Statement

Copyright held by author or publisher. User is responsible for all copyright compliance.

This document is currently not available here.

Share

COinS