Publication Date

8-1-2017

Document Type

Article

Organizational Units

College of Arts Humanities and Social Sciences, Psychology

Keywords

Childhood abuse, Maltreatment, Trauma, fMRI, Inhibition, Cognitive control

Abstract

Background

Although limited, the literature suggests alterations in activation of cognitive control regions in adults and adolescents with a history of childhood abuse. The current study examined whether such alterations are increased in the face of emotionally-distracting as compared to emotionally neutral information, and whether such alterations occur in brain regions that exert cognitive control in a more top-down sustained manner or a more bottom-up transient manner.

Methods

Participants were young adult women (ages 23–30): one group with a history of childhood physical or sexual abuse (N = 15) and one with no trauma exposure (N = 17), as assessed through the Trauma History Questionnaire and a two-stage interview adapted from the National Crime Victims Survey. Participants underwent fMRI scanning while completing hybrid block/event-related versions of a classic color-word and an emotional Stroop paradigm (threat and positive words). This paradigm allowed us to examine both sustained (activation persisting across blocks) and transient (event-specific activation) aspects of cognitive control.

Results

Women with a history of childhood abuse demonstrated decreased recruitment of frontal-parietal regions involved in cognitive control and enhanced recruitment of a ventral attention surveillance network during blocks of both versions of the Stroop task. Additionally, they had less suppression of brain regions involved in self-referential processes for threat blocks, but greater suppression of these regions for positive blocks. Severity of avoidance symptoms was associated with sustained activation in lateral prefrontal regions, whereas hyperarousal/re-experiencing symptoms were associated with sustained activity in temporal regions. No differential effects were observed for transient control.

Conclusions

Results suggest exposure to childhood abuse is associated with blunted recruitment of brain regions supporting task-set maintenance but hypervigilance for task-irrelevant information, regardless of whether distractors are emotionally neutral or emotional. Exposure to childhood abuse is also associated with less suppression of default mode brain regions associated with self-referential processing in the face of irrelevant threat information, but heightened ability to suppress similar processing for irrelevant positive information.

Copyright Date

8-1-2017

Copyright Statement / License for Reuse

Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Publication Statement

Copyright is held by the authors. User is responsible for all copyright compliance. This article was originally published as:

Mackiewicz Seghete, K. L., Kaiser, R. H., DePrince, A. P., & Banich, M. T. (2017). General and emotion-specific alterations to cognitive control in women with a history of childhood abuse. NeuroImage Clinical, 16, 151-164. https://doi.org/10.1016/j.nicl.2017.06.030

Rights Holder

Kristen L. Mackiewicz Seghete, Roselinde H. Kaiser, Anne P. DePrince, Marie T. Banich

Provenance

Received from CHORUS

File Format

application/pdf

Language

English (eng)

Extent

14 pgs

File Size

716 KB

Publication Title

NeuroImage: Clinical

Volume

16

First Page

151

Last Page

164

ISSN

2213-1582

PubMed ID

28794976



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