Aortic valve disease is a common condition in patients above 60 years of age and is associated with significant morbidity and mortality. Aortic valve stenosis is characterized by the narrowing of the aortic valve, which can be quite debilitating. This disease is treated with transcatheter aortic valve replacement (TAVR), which is a rapidly expanding alternative to open-heart surgical aortic valve replacement (SAVR). Although TAVR is a less invasive than SAVR, long-term durability of the transcatheter aortic valves could be the Achilles heel of the procedure. Thus, the main objective of this research was to improve the design of transcatheter aortic valves using experimental testing and design analysis. After the design, building, and testing phases of four differing valves, it was seen that there are benefits to two specific designs. One design was a TAV based on a native aortic valve while the other was a TAV geometry that was optimized by finite element modeling. The native valve performed well during diastole based on its average regurgitation volume, while the optimized valve performed well during systole based on its average positive pressure difference and effective orifice area.

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