Patient-Specific Quantification of the Relationship Between the Left Atrium Pressure and the Ostial Diameter of the Left Atrial Appendage
Date of Award
Ali N. Azadani, Ph.D.
LAA, Left atrial appendage, Appendage, FEA, Finite element analysis
The left atrial appendage has been a historically understudied region of the heart until fairly recently with the new understanding of its role in the stroke pathway of patients with atrial fibrillation. The goal of this study is to take a look at the biomechanical behavior of the left atrium and left atrial appendage under normal physiological loading conditions using material properties taken from biaxial stretch tests. Several different options for material properties models were tested and biaxial stretch test data of cadaveric human tissue samples for the left atrium and appendage were fit to a Fung-type strain-energy function for input into simulation. Simulations were performed on geometry of the left atrium and appendage extracted from computed tomographical images of a single patient spanning from the pulmonary veins to the mitral valve annulus. Physiological pressure loading conditions were simulated at 5 mmHg, 7.5 mmHg, 10 mmHg, 15 mmHg, and 20 mmHg over two cardiac cycles. Results showed that peak stresses and strains were concentrated at branches in the atrium as well as the ostial entrance to the appendage. Ostial diameter of the appendage was measured across to axes and showed increases from a baseline of 1.347 cm x 2.927 cm in the unloaded configuration up to a size of 1.749 cm x 3.219 cm in the loaded configuration. Finite element simulations may be a useful tool for improving patient treatment options, especially when it comes to mechanical left atrial appendage occlusion devices.
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Gao, Sky Tianqi, "Patient-Specific Quantification of the Relationship Between the Left Atrium Pressure and the Ostial Diameter of the Left Atrial Appendage" (2018). Electronic Theses and Dissertations. 1538.
Received from ProQuest
Sky Tianqi Gao
Biomechanics Commons, Cardiology Commons, Cardiovascular System Commons, Physiology Commons