Scholarship created by the faculty of the University of Denver's Knoebel Institute for Healthy Aging.


Submissions from 2022


Foldamers Reveal and Validate Therapeutic Targets Associated with Toxic α-Synuclein Self-Assembly, Jemil Ahmed, Tessa C. Fitch, Courtney M. Donnelly, Johnson A. Joseph, Tyler D. Ball, Mikaela M. Bassil, Ahyun Son, Chen Zhang, Aurélie Ledreux, Scott Horowitz, Yan Qin, Daniel Paredes, and Sunil Kumar

Submissions from 2020

Traumatic Brain Injury Increases Plasma Astrocyte‐derived Exosome Levels of Neurotoxic Complement Proteins, Edward J. Goetzl, Kristine Yaffe, Carrie B. Peltz, Aurélie Ledreux, Kim Gorgens, Bradley S. Davidson, Ann‐Charlotte Granholm, Maja Mustapic, Dimitrios Kapogiannis, David Tweedie, and Nigel H. Greig

Submissions from 2019

Altered Levels of Plasma Neuron-derived Exosomes and their Cargo Proteins Characterize Acute and Chronic Mild Traumatic Brain Injury, Edward J. Goetzl, Fanny M. Elahi, Maja Mustapic, Dimitrios Kapogiannis, Moira Pryhoda, Anah Gilmore, Kim Gorgens, Bradley S. Davidson, Ann‐Charlotte Granholm, and Aurélie Ledreux

Exosome Release and Cargo in Down Syndrome, Eric D. Hamlett, Angela LaRosa, Elliott J. Mufson, Juan Fortea, Aurélie Ledreux, and Ann‐Charlotte Granholm

Inhibitory Designer Receptors Aggravate Memory Loss in a Mouse Model of Down Syndrome, Eric D. Hamlett, Aurélie Ledreux, Anah Gilmore, Elena M. Vazey, Gary Aston-Jones, Heather A. Boger, Daniel Paredes, and Ann‐Charlotte Granholm

DNA Facilitates Oligomerization and Prevents Aggregation via DNA Networks, Theodore J. Litberg, Brianne Docter, Michael P. Hughes, Jennifer Bourne, and Scott Horowitz

The CRISPR-Cas9 crADSL HeLa Transcriptome: A First Step in Establishing a Model for ADSL Deficiency and SAICAR Accumulation, Randall C. Mazzarino, Veronika Baresova, Marie Zikánová, Nathan Duval, Terry G. Wilkinson, David Patterson, and Guido N. Vacano

Submissions from 2018

Loss of DNA Polymerase β induces Cellular Senescence, Aqila A. Ahmed, Cristine Smoczer, Brianna Pace, David Patterson, and Diane Cress Cabelof

The Cysteine-rich Whey Protein Supplement, Immunocal®, Preserves Brain Glutathione and Improves Cognitive, Motor, and Histopathological Indices of Traumatic Brain Injury in a Mouse Model of Controlled Cortical Impact, Elizabeth Ignowski, Aimee N. Winter, Nathan Duval, Holly Fleming, Tyler Wallace, Evan Manning, Lilia Koza, Kendra Huber, Natalie J. Serkova, and Daniel A. Linseman

Submissions from 2017

A Noradrenergic Lesion Aggravates the Effects of Systemic Inflammation on the Hippocampus of Aged Rats, Krishna L. Bharani, Rebecca Derex, Ann‐Charlotte Granholm, and Aurélie Ledreux

Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice, Mona Buhusi, Chris Etheredge, Ann‐Charlotte Granholm, and Catalin V. Buhusi

Exosomal Biomarkers in Down Syndrome and Alzheimer's Disease, Eric D. Hamlett, Aurélie Ledreux, Huntington Potter, Heidi J. Chial, David Patterson, Joaquin M. Espinosa, Brianne M. Bettcher, and Ann‐Charlotte Granholm

Folding while Bound to Chaperones, Scott Horowitz, Philipp Koldewey, Frederick Stull, and James CA Bardwell

The Mechanism of HdeA Unfolding and Chaperone Activation, Loïc Salmon, Frederick Stull, Sabrina Sayle, Claire Cato, Şerife Akgül, Linda Foit, Logan S. Ahlstrom, Elan Z. Eisenmesser, Hashim M. Al-Hashimi, James C.A. Bardwell, and Scott Horowitz

Proteomic Analysis of Six- and Twelve-month Hippocampus and Cerebellum in a Murine Down Syndrome Model, Guido N. Vacano, David S. Gibson, Abdullah Arif Turjoman, Jeremy W. Gawryluk, Jonathan D. Geiger, Mark Duncan, and David Patterson

Submissions from 2016

Neuronal Exosomes Reveal Alzheimer's Disease Biomarkers in Down Syndrome, Eric D. Hamlett, Edward J. Goetzl, Aurélie Ledreux, Vitaly Vasilevko, Heather A. Boger, Angela LaRosa, David Clark, Steven L. Carroll, María Carmona-Iragui, Juan Fortea, Elliott J. Mufson, Marwan Sabbagh, Abdul H. Mohammed, Dean Hartley, Eric Doran, Ira T. Lott, and Ann‐Charlotte Granholm