Infant Hippocampal and Amygdala Volume in an Observational Follow-Up from a Randomized Clinical Trial for Maternal Prenatal Depression

Authors

• Catherine H. Demers, University of Denver, University of Colorado Anschutz Medical CampusFollow
• Benjamin L. Hankin, University of Illinois at Urbana-Champaign
• LillyBelle K. Deer, University of Utah
• Robert J. Gallop, West Chester University
• Mercedes Hoeflich Haase, University of North Carolina at Chapel Hill
• M. Camille Hoffman, University of Colorado Anschutz Medical Campus, University of Colorado Denver
• Martin A. Styner, University of North Carolina at Chapel Hill
• Nancy K. Grote, University of Washington
• Elysia Poggi Davis, University of Denver, University of California IrvineFollow

Publication Date

7-20-2026

Document Type

Data Set

Organizational Units

College of Arts Humanities and Social Sciences, Psychology

Keywords

Prenatal depression, Brain development, Hippocampus, Amygdala, Interpersonal psychotherapy

Abstract

Prenatal maternal depression may have intergenerational effects on offspring brain development, with potential socioemotional consequences. In an observational follow-up of a randomized clinical trial of a prenatal depression intervention (the CARE Project; ClinicalTrials.gov NCT03011801), brain development and subsequent negative emotionality were examined among 109 infants born to mothers randomized during pregnancy to brief interpersonal psychotherapy or enhanced usual care. These data include MRI-derived hippocampal and amygdala volumes at approximately 6 weeks of age and a laboratory-based assessment of infant negative emotionality at 6 months.

Resulting Publication: Infant hippocampal and amygdala volume in an observational follow-up from a randomized clinical trial for maternal prenatal depression.

Copyright Date

7-12-2026

Copyright Statement / License for Reuse

All Rights Reserved.

Rights Holder

The Authors

Provenance

Received from Author

File Format

application/zip

Language

English (eng)

File Size

20.8 KB

Publication Statement

Copyright is held by the author. User is responsible for all copyright compliance.

Supplementary File Description

Zip File Contains:

1. RCT Brain Data Repository
   File Format(s): .sav (9.19 KB) and .csv (7.53 KB)
2. Code Book
   File Format: .docx (16.1 KB)

Recommended Citation

Demers, Catherine H.; Hankin, Benjamin L.; Deer, LillyBelle K.; Gallop, Robert J.; Haase, Mercedes Hoeflich; Hoffman, M. Camille; Styner, Martin A.; Grote, Nancy K.; and Davis, Elysia Poggi, "Infant Hippocampal and Amygdala Volume in an Observational Follow-Up from a Randomized Clinical Trial for Maternal Prenatal Depression" (2026). Psychology: Data Sets. 1.
https://digitalcommons.du.edu/psychology_data/1 https://doi.org/10.56902/Data.Psych.2026.1

DOI Link

https://doi.org/10.56902/Data.Psych.2026.1