Publication Date
4-26-2016
Document Type
Article
Organizational Units
College of Natural Science and Mathematics, Biological Sciences
Keywords
Adrenocorticotropic hormone (ACTH), Dasyatis akajei, Melanocortin receptor (MCR), Melanocyte-stimulating hormone (MSH), Stingray
Abstract
This article contains structure and pharmacological characteristics of melanocortin receptors (MCRs) related to research published in “Characterization of melanocortin receptors from stingray Dasyatis akajei, a cartilaginous fish” (Takahashi et al., 2016) [1]. The amino acid sequences of the stingray, D. akajei, MC1R, MC2R, MC3R, MC4R, and MC5R were aligned with the corresponding melanocortin receptor sequences from the elephant shark, Callorhinchus milii, the dogfish, Squalus acanthias, the goldfish, Carassius auratus, and the mouse, Mus musculus. These alignments provide the basis for phylogenetic analysis of these gnathostome melanocortin receptor sequences. In addition, the Japanese stingray melanocortin receptors were separately expressed in Chinese Hamster Ovary cells, and stimulated with stingray ACTH, α-MSH, β-MSH, γ-MSH, δ-MSH, and β-endorphin. The dose response curves reveal the order of ligand selectivity for each stingray MCR.
Copyright Date
4-26-2016
Copyright Statement / License for Reuse
This work is licensed under a Creative Commons Attribution 4.0 International License.
Rights Holder
The Authors
Provenance
Received from author
File Format
application/pdf
Language
English (eng)
Extent
8 pgs
File Size
1113 KB
Publication Statement
Copyright is held by the authors. User is responsible for all copyright compliance. This article was originally published as:
Takahashi, A., Davis, P., Reinick, C., Mizusawa, K., Sakamoto, T., & Dores, R. M. (2016). Data for amino acid alignment of Japanese stingray melanocortin receptors with other gnathostome melanocortin receptor sequences, and the ligand selectivity of Japanese stingray melanocortin receptors. Data in Brief, 7, 1670–1677. DOI: 10.1016/j.dib.2016.04.050
Publication Title
Data in Brief
Volume
7
First Page
1670
Last Page
1677
ISSN
2352-3409
Recommended Citation
Takahashi, A., Davis, P., Reinick, C., Mizusawa, K., Sakamoto, T., & Dores, R. M. (2016). Data for amino acid alignment of Japanese stingray melanocortin receptors with other gnathostome melanocortin receptor sequences, and the ligand selectivity of Japanese stingray melanocortin receptors. Data in Brief, 7, 1670–1677. DOI: 10.1016/j.dib.2016.04.050