Date of Award
1-1-2016
Document Type
Masters Thesis
Degree Name
M.S.
Organizational Unit
Chemistry and Biochemistry
First Advisor
Brian W. Michel, Ph.D.
Second Advisor
Sandra Eaton
Third Advisor
Bryan Cowen
Fourth Advisor
James Fogleman
Keywords
8-Vinylquinoline, Alkene, Catalyzed, Difunctionalization, Oxidation, Palladium
Abstract
The synthesis of quinoline derivatives is a continuing issue facing organic chemists in both academia and industry. To address this problem, palladium-catalyzed alkene difunctionalization was developed to be a powerful and straightforward strategy of synthetic transformations for adding diversity to organic molecules. In this thesis, Pd-catalyzed olefin difunctionalization reactions of vinyl-quinoline type substrate via generating Pd-alkyl intermediates were mainly described. The reactions described herein are pursuing three significant goals: 1) to isolate and recrystallize Pd-alkyl complexes; 2) to achieve oxidation reactions on Pd-alkyl intermediate; and 3) to investigate stereochemistry of nucleopalladation step on vinyl-quinoline starting materials.
Publication Statement
Copyright is held by the author. User is responsible for all copyright compliance.
Rights Holder
Lusha Xu
Provenance
Received from ProQuest
File Format
application/pdf
Language
en
File Size
54 p.
Recommended Citation
Xu, Lusha, "Development of Palladium Catalyzed Alkene Difunctionalization on Vinyl-Quinoline Type Substrate and Isolation of Pd-Alkyl Intermediate" (2016). Electronic Theses and Dissertations. 1185.
https://digitalcommons.du.edu/etd/1185
Copyright date
2016
Discipline
Chemistry