Date of Award
Cynthia A. McRae, Ph.D.
Behavioral medicine, Deep brain stimulation, Movement disorders, Parkinson Disease, Psychology, Quality of life
Quality of Life (QOL) in Parkinson's disease (PD) patients after Deep Brain Stimulation (DBS) neurosurgery generally improves between 3 to 24 months post-operatively. However, QOL beyond 2 year follow-up is generally unknown. This study examined the QOL in 16 advanced PD patients who received DBS at an average of 7.5 year follow-up with the Parkinson's Disease Questionnaire (PDQ-39). Participants had an average Disease Duration of 20.57 years (SD 5.7) and a mean Age of 63.50 (SD 8.05). Linear regression analyses suggested a constellation of changes involving Time, Age, and Disease Duration. As Time progressed since DBS intervention, the PDQ-39 Cognitions subscale worsened (p < .05). Increasing Age was associated with improvement in Stigma-related QOL (p < .01). Rising Disease Duration correlated with improvements in three PDQ-39 subscales: (a) Stigma (p < .01), (b) Emotional Well-Being (p < .01), and (c) Social Support (p < .05). Findings suggested the need to further explore the domains and dimensions of QOL change post-DBS intervention, as well as other methods to measure the depth and breadth of QOL in DBS recipients.
Chiang, Karl S., "Trajectory of Quality of Life in Advanced Parkinson's Patients Receiving Bilateral Subthalamic Nucleus Deep Brain Stimulation" (2009). Electronic Theses and Dissertations. 124.
Received from ProQuest
Karl S. Chiang
Clinical psychology, Mental health, Behavioral sciences