Date of Award

2020

Document Type

Masters Thesis

Degree Name

M. S.

Organizational Unit

Daniel Felix Ritchie School of Engineering and Computer Science, Mechanical and Materials Engineering

First Advisor

Ali N. Azadani

Second Advisor

Chadd W. Clary

Third Advisor

James Fogleman

Keywords

Durability, Mitral valve, Transcatheter

Abstract

Transcatheter mitral valve replacement (TMVR) is being developed to become a substitute therapy for surgery in prohibitive or high surgical risk patients to treat severe mitral regurgitation. A limited number of TMVR systems are under clinical evaluation. However, transcatheter mitral valve (TMV) long-term durability and hemodynamic performance is not known. TMV durability and hemodynamics must match with that of surgical bioprostheses for potential commercialization of TMVR. Experimental and computational approaches were used to find the leaflets’ three-dimensional anisotropic mechanical properties in a transcatheter Edwards SAPIEN 3 valve and a surgical Carpentier-Edwards PERIMOUNT Magna mitral valve and finite element (FE) simulations were conducted to obtain the stress distribution on both valves. Moreover, to visualize the flow field within the left heart, steady-state computational fluid dynamics (CFD) simulations were run. The FE simulations demonstrated that in a cardiac cycle, at peak systole, the highest stress value in the two bioprostheses was 4.75 and 16 MPa for the surgical and transcatheter heart valve, respectively. After studying the leaflet stress distributions and flow field, long-term durability may potentially be different between the two models. The results of CFD simulations could potentially show that TMVs with supra-annular positioning have a higher risk of leaflet thrombosis as opposed to the intra-annular position.

Publication Statement

Copyright is held by the author. User is responsible for all copyright compliance.

Rights Holder

Saba Ravaghi

Provenance

Received from ProQuest

File Format

application/pdf

Language

en

File Size

65 p.

Discipline

Biomedical engineering, Mechanical engineering

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