Date of Award


Document Type

Masters Thesis

Degree Name


Organizational Unit

Daniel Felix Ritchie School of Engineering and Computer Science, Mechanical and Materials Engineering

First Advisor

Ali N. Azadan

Second Advisor

Matt H. Gordon

Third Advisor

Anna A. Sher


Mitral regurgitation, Fluid dynamics


Mitral regurgitation (MR) is a prominent cardiac disease affecting more than two million people in the United States alone. In order for patients to receive proper therapy, regurgitant volume must first be quantified. As there are an array of methods to do so, the proximal isovelocity surface area (PISA) method continues to be the most accurate and clinically used method. However, there are some difficulties obtaining the necessary measurements need for this when performing transthoracic echocardiography. This study aims to evaluate and present techniques that may be used to more accurately quantify regurgitation through ex vivo testing and computational fluid dynamic simulations. Both a steady and pulsatile flow system were created to test clinical applications used to quantify MR using the PISA method. A total of six computational fluid dynamic cases were then studied; three native mitral valves effected by MR as well as three valves enacting to have MitraClip implantation, both sets of having a MR grade of mild, moderate, and severe. All cases were effected by an eccentric ellipse orifice(s). Flow rate was evaluated in each case, comparing actual flow rate to calculated flow rate, which was found implementing the modified hemielliptic PISA model. The results of this study implicate that clinical techniques used to quantify MR need an experienced technician, as well as further developing current techniques used, which is best done through ex vivo testing. The study further implied that severity may be significantly underestimated when quantifying MR using the modified hemielliptic PISA method in the short view.

Publication Statement

Copyright is held by the author. User is responsible for all copyright compliance.

Rights Holder

Alexandra Flowers


Received from ProQuest

File Format




File Size

80 pgs


Bioengineering, Biomechanics, Mechanical engineering