Date of Award

2022

Document Type

Masters Thesis

Degree Name

M.S.

Organizational Unit

College of Natural Science and Mathematics, Chemistry and Biochemistry

First Advisor

Brady T. Worrell

Second Advisor

Brian Michel

Third Advisor

Sunil Kumar

Keywords

Carbon monoxide releasing molecules (CORM), Diphenylcyclopropenone, Quantum Chain Reaction

Abstract

Despite the commonly held consensus that carbon monoxide (CO) is toxic, it has been shown to be an essential signaling molecule in the human neuronal system and has been noted to have anti-inflammatory properties, act as a vasodilator, have anti-proliferative impacts on tumors, and many other beneficial effects. The current limitation to using CO as a therapeutic molecule is delivering the proper dosages using CO releasing molecules (CORMs) without exhibiting toxicity. The first chapter of this thesis will review the biological significance of CO in biological systems, the limitations of existing CORMs, and the properties of diphenylcyclopropenone (DPCP) that make it a promising CORM. The second chapter of this thesis will describe our work to develop a new class of directly polymerizable organic CORMs based on DPCP.

Publication Statement

Copyright is held by the author. User is responsible for all copyright compliance.

Rights Holder

Jackson Snow

Provenance

Received from ProQuest

File Format

application/pdf

Language

en

File Size

148 pgs

Discipline

Chemistry, Polymer chemistry

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