Date of Award
2022
Document Type
Thesis
Degree Name
M.S.
Department
Chemistry and Biochemistry
First Advisor
Brady T. Worrell
Second Advisor
Brian Michel
Third Advisor
Sunil Kumar
Keywords
Carbon monoxide releasing molecules (CORM), Diphenylcyclopropenone, Quantum Chain Reaction
Abstract
Despite the commonly held consensus that carbon monoxide (CO) is toxic, it has been shown to be an essential signaling molecule in the human neuronal system and has been noted to have anti-inflammatory properties, act as a vasodilator, have anti-proliferative impacts on tumors, and many other beneficial effects. The current limitation to using CO as a therapeutic molecule is delivering the proper dosages using CO releasing molecules (CORMs) without exhibiting toxicity. The first chapter of this thesis will review the biological significance of CO in biological systems, the limitations of existing CORMs, and the properties of diphenylcyclopropenone (DPCP) that make it a promising CORM. The second chapter of this thesis will describe our work to develop a new class of directly polymerizable organic CORMs based on DPCP.
Publication Statement
Copyright is held by the author. User is responsible for all copyright compliance.
Recommended Citation
Snow, Jackson, "Directly Polymerizable CO Releasing Molecules" (2022). Electronic Theses and Dissertations. 2161.
https://digitalcommons.du.edu/etd/2161
Provenance
Received from ProQuest
Rights holder
Jackson Snow
File size
148 pgs
Copyright date
2022
File format
application/pdf
Language
en
Discipline
Chemistry, Polymer chemistry