Publication Date

11-2017

Document Type

Article

Organizational Units

College of Arts Humanities and Social Sciences, Psychology

Keywords

P factor, Internalizing, Externalizing, Middle childhood, Gray matter volume

Abstract

Reduced gray matter volume (GMV) is widely implicated in psychopathology, but scholars have found mostly overlapping areas of GMV reduction across disorders rather than unique neural signatures, potentially due to pervasive comorbidity. GMV reductions may be associated with broader psychopathology dimensions rather than specific disorders. We used an empirically supported bifactor model consisting of common psychopathology and internalizing- and externalizing-specific factors to evaluate whether latent psychopathology dimensions yield a clearer, more parsimonious pattern of GMV reduction in prefrontal and limbic/paralimbic areas implicated in individual disorders. A community sample of children (N = 254, ages 6–10) was used to evaluate whether GMV reductions could constitute early neural risk factors. The common psychopathology factor was associated with reduced GMV in prefrontal areas (dorsal, orbitofrontal, ventrolateral). The internalizing-specific factor was related to reduced GMV in limbic/paralimbic areas (hippocampus, amygdala, insula). No significant associations were found between GMV and the externalizing-specific factor after accounting for common psychopathology.

Copyright Date

7-26-2017

Copyright Statement / License for Reuse

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Statement

Copyright is held by the authors and Sage Publications. User is responsible for all copyright compliance. This article was originally published as:

Snyder, H. R., Hankin, B. L., Sandman, C. A., Head, K., & Davis, E. P. (2017). Distinct patterns of reduced prefrontal and limbic gray matter volume in childhood general and internalizing psychopathology. Clinical Psychological Science, 5(6), 1001-1013. https://doi.org/10.1177/2167702617714563

Accepted Manuscript is openly available with a CC BY 4.0 license through the "Download" button. Originally retrieved from https://escholarship.org/uc/item/4030887c

The published Version of Record is available at libraries through Compass or Worldcat with All Rights Reserved.

Rights Holder

Hannah R. Snyder, Benjamin L. Hankin, Curt A. Sandman, Kevin Head, Elysia P. Davis, and Sage Publications

Provenance

Received from CHORUS

File Format

application/pdf

Language

English (eng)

Extent

21 pgs

File Size

670 KB

Publication Title

Clinical Psychological Science

Volume

5

Issue

6

First Page

1001

Last Page

1013

ISSN

2167-7034

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