Distinct Patterns of Reduced Prefrontal and Limbic Gray Matter Volume in Childhood General and Internalizing Psychopathology
Publication Date
11-2017
Document Type
Article
Organizational Units
College of Arts Humanities and Social Sciences, Psychology
Keywords
P factor, Internalizing, Externalizing, Middle childhood, Gray matter volume
Abstract
Reduced gray matter volume (GMV) is widely implicated in psychopathology, but scholars have found mostly overlapping areas of GMV reduction across disorders rather than unique neural signatures, potentially due to pervasive comorbidity. GMV reductions may be associated with broader psychopathology dimensions rather than specific disorders. We used an empirically supported bifactor model consisting of common psychopathology and internalizing- and externalizing-specific factors to evaluate whether latent psychopathology dimensions yield a clearer, more parsimonious pattern of GMV reduction in prefrontal and limbic/paralimbic areas implicated in individual disorders. A community sample of children (N = 254, ages 6–10) was used to evaluate whether GMV reductions could constitute early neural risk factors. The common psychopathology factor was associated with reduced GMV in prefrontal areas (dorsal, orbitofrontal, ventrolateral). The internalizing-specific factor was related to reduced GMV in limbic/paralimbic areas (hippocampus, amygdala, insula). No significant associations were found between GMV and the externalizing-specific factor after accounting for common psychopathology.
Copyright Date
7-26-2017
Copyright Statement / License for Reuse
All Rights Reserved.
Rights Holder
Hannah R. Snyder, Benjamin L. Hankin, Curt A. Sandman, Kevin Head, Elysia P. Davis, and Sage Publications
Provenance
Received from CHORUS
File Format
application/pdf
Language
English (eng)
Extent
21 pgs
File Size
670 KB
Publication Statement
Copyright is held by the authors and Sage Publications. User is responsible for all copyright compliance. This article was originally published as:
Snyder, H. R., Hankin, B. L., Sandman, C. A., Head, K., & Davis, E. P. (2017). Distinct patterns of reduced prefrontal and limbic gray matter volume in childhood general and internalizing psychopathology. Clinical Psychological Science, 5(6), 1001-1013. https://doi.org/10.1177/2167702617714563
Accepted Manuscript is available through the "Link to Full Text" button.
The published Version of Record is available at libraries through Compass or Worldcat with All Rights Reserved.
Publication Title
Clinical Psychological Science
Volume
5
Issue
6
First Page
1001
Last Page
1013
ISSN
2167-7034
PubMed ID
29399423
Recommended Citation
Snyder, H. R., Hankin, B. L., Sandman, C. A., Head, K., & Davis, E. P. (2017). Distinct patterns of reduced prefrontal and limbic gray matter volume in childhood general and internalizing psychopathology. Clinical Psychological Science, 5(6), 1001-1013. https://doi.org/10.1177/2167702617714563