Prenatal Maternal Stress, Child Cortical Thickness, and Adolescent Depressive Symptoms

Publication Date

3-6-2020

Document Type

Article

Organizational Units

College of Arts Humanities and Social Sciences, Psychology

Keywords

Prenatal maternal stress, Depressive symptoms, Youth, Pregnancy, Cortical thickness

Abstract

Prenatal maternal stress predicts subsequent elevations in youth depressive symptoms, but the neural processes associated with these links are unclear. This study evaluated whether prenatal maternal stress is associated with child brain development, and adolescent depressive symptoms using a prospective design with 74 mother child pairs (40 boys). Maternal stress was assessed during pregnancy, child cortical thickness at age 7, and depressive symptoms at age 12. Prenatal maternal stress was associated with less cortical thickness primarily in frontal and temporal regions and with elevated depressive symptoms; child cortical thickness additionally correlated with adolescent depressive symptoms. The observed associations are consistent with the possibility that cortical thickness in superior frontal regions links associations between prenatal maternal stress and adolescent depressive symptoms.

Copyright Date

5-9-2019

Copyright Statement / License for Reuse

All Rights Reserved
All Rights Reserved.

Rights Holder

Society for Research in Child Development

Provenance

Received from CHORUS

Language

English (eng)

Publication Statement

Copyright is held by the Society for Research in Child Development. User is responsible for all copyright compliance. This article was originally published as:

Poggi Davis, E., Hankin, B. L., Glynn, L. M., Head, K., Kim, D. J., & Sandman, C. A. (2020). Prenatal maternal stress, child cortical thickness, and adolescent depressive symptoms. Child Development, 91(2), e432-e450. https://doi.org/10.1111/cdev.13252

Publication Title

Child Development

Volume

91(2)

First Page

e432

Last Page

e450

ISSN

1467-8624

PubMed ID

31073997

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