Publication Date

11-13-2017

Document Type

Article

Organizational Units

College of Arts Humanities and Social Sciences, Psychology

Keywords

Cumulative risk, Diffusion tensor imaging (DTI), Family income, Middle childhood, White matter

Abstract

Family income is associated with gray matter morphometry in children, but little is known about the relationship between family income and white matter structure. In this paper, using Tract-Based Spatial Statistics, a whole brain, voxel-wise approach, we examined the relationship between family income (assessed by income-to-needs ratio) and white matter organization in middle childhood (N = 27, M = 8.66 years). Results from a non-parametric, voxel-wise, multiple regression (threshold-free cluster enhancement, p < 0.05 FWE corrected) indicated that lower family income was associated with lower white matter organization [assessed by fractional anisotropy (FA)] for several clusters in white matter tracts involved in cognitive and emotional functions including fronto-limbic circuitry (uncinate fasciculus and cingulum bundle), association fibers (inferior longitudinal fasciculus, superior longitudinal fasciculus), and corticospinal tracts. Further, we examined the possibility that cumulative risk (CR) exposure might function as one of the potential pathways by which family income influences neural outcomes. Using multiple regressions, we found lower FA in portions of these tracts, including those found in the left cingulum bundle and left superior longitudinal fasciculus, was significantly related to greater exposure to CR (β = -0.47, p < 0.05 and β = -0.45, p < 0.05).

Copyright Date

11-13-2017

Copyright Statement / License for Reuse

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Rights Holder

Alexander J. Dufford and Pilyoung Kim

Provenance

Received from CHORUS

File Format

application/pdf

Language

English (eng)

Extent

13 pgs

File Size

743 KB

Publication Statement

Copyright is held by the authors. User is responsible for all copyright compliance. This article was originally published as:

Dufford, A. J., & Kim, P. (2017). Family income, cumulative risk exposure, and white matter structure in middle childhood. Frontiers in Human Neuroscience, 11, 547. https://doi.org/10.3389/fnhum.2017.00547

Publication Title

Frontiers in Human Neuroscience

Volume

11

First Page

547

ISSN

1662-5161

PubMed ID

29180959

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