5-HTTLPR×interpersonal Stress Interaction and Nonsuicidal Self-injury in General Community Sample of Youth

Publication Date

2-28-2015

Document Type

Article

Organizational Units

College of Arts Humanities and Social Sciences, Psychology

Keywords

NSSI, G⁎E, Interpersonal stress, Youth

Abstract

No research with youth has investigated whether measured genetic risk interacts with stressful environment (G⁎E) to explain engagement in non-suicidal self-injury (NSSI). Two independent samples of youth were used to test the a priori hypothesis that the Transporter-Linked Polymorphic Region (5-HTTLPR) would interact with chronic interpersonal stress to predict NSSI. We tested this hypothesis with children and adolescents from United States public schools in two independent samples (N׳s=300 and 271) using identical procedures and methods. They were interviewed in person with the Self-Injurious Thoughts and Behaviors Interview to assess NSSI engagement and with the UCLA Chronic Stress Interview to assess interpersonal stress. Buccal cells were collected for genotyping of 5-HTTLPR. For both samples, ANOVAs revealed the hypothesized G⁎E. Specifically, short carriers who experienced severe interpersonal stress exhibited the highest level of NSSI engagement. Replicated across two independent samples, results provide the first demonstration that youth at high genetic susceptibility (5-HTTLPR) and high environmental exposure (chronic interpersonal stress) are at heightened risk for NSSI.

Copyright Date

12-3-2014

Copyright Statement / License for Reuse

All Rights Reserved
All Rights Reserved.

Rights Holder

Elsevier

Provenance

Received from author

Language

English (eng)

Extent

4 pgs

Publication Statement

Copyright held by Elsevier Ireland Ltd. User is responsible for all copyright compliance.

Publication Title

Psychiatry Research

Volume

225

Issue

3

First Page

609

Last Page

612

ISSN

1872-7123

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