Date of Award
6-2023
Document Type
Masters Thesis
Degree Name
M.S.
Organizational Unit
Daniel Felix Ritchie School of Engineering and Computer Science, Mechanical and Materials Engineering
First Advisor
Ali Azadani
Second Advisor
Matt Gordon
Third Advisor
Laleh Mehran
Keywords
Cardiovascular mechanics, Data analysis, Fluid structure analysis, Heart valves, Hemodynamics, Numerical analysis
Abstract
Aortic stenosis impacts approximately 7% of the global population. In the past decade, the role of computational modeling has been becoming considerably important in the design of BHVs. To obtain reliable solutions in computational modeling, it is essential to consider accurate properties of bioprosthetic heart valves (BHVs), such as density and mechanical properties. Previous computational studies assumed (bovine pericardium) BP used in BHVs density was comparable to water or blood. Yet, BP is subjected to multiple treatments like fixation and anti-calcification. In Chapter 2, I measured BP density and its effect on BHV leaflet stress and strain. In the second study, Chapter 3, I’ve developed a new framework to investigate the bioprosthetic heart valve (BHV) interaction with the blood flow passing through the valve inside a pulse duplicator system. This project is a major step towards the experimental validation of FSI modeling for analyzing tissue heart valves.
Copyright Date
6-2023
Copyright Statement / License for Reuse
All Rights Reserved.
Publication Statement
Copyright is held by the author. User is responsible for all copyright compliance.
Rights Holder
Masod Sadipour
Provenance
Received from ProQuest
File Format
application/pdf
Language
English (eng)
Extent
67 pgs
File Size
2.2 MB
Recommended Citation
Sadipour, Masod, "Fully Coupled Fluid Structure Interaction Simulation of Bioprosthetic Heart Valves: A Numerical and Experimental Analysis" (2023). Electronic Theses and Dissertations. 2321.
https://digitalcommons.du.edu/etd/2321
Discipline
Biomedical engineering, Engineering