Date of Award


Document Type

Masters Thesis

Degree Name


Organizational Unit

Daniel Felix Ritchie School of Engineering and Computer Science, Mechanical and Materials Engineering

First Advisor

Ali Azadani

Second Advisor

Matt Gordon

Third Advisor

Laleh Mehran


Cardiovascular mechanics, Data analysis, Fluid structure analysis, Heart valves, Hemodynamics, Numerical analysis


Aortic stenosis impacts approximately 7% of the global population. In the past decade, the role of computational modeling has been becoming considerably important in the design of BHVs. To obtain reliable solutions in computational modeling, it is essential to consider accurate properties of bioprosthetic heart valves (BHVs), such as density and mechanical properties. Previous computational studies assumed (bovine pericardium) BP used in BHVs density was comparable to water or blood. Yet, BP is subjected to multiple treatments like fixation and anti-calcification. In Chapter 2, I measured BP density and its effect on BHV leaflet stress and strain. In the second study, Chapter 3, I’ve developed a new framework to investigate the bioprosthetic heart valve (BHV) interaction with the blood flow passing through the valve inside a pulse duplicator system. This project is a major step towards the experimental validation of FSI modeling for analyzing tissue heart valves.

Copyright Date


Copyright Statement / License for Reuse

All Rights Reserved
All Rights Reserved.

Publication Statement

Copyright is held by the author. User is responsible for all copyright compliance.

Rights Holder

Masod Sadipour


Received from ProQuest

File Format



English (eng)


67 pgs

File Size

2.2 MB


Biomedical engineering, Engineering