Date of Award

Spring 6-13-2025

Document Type

Masters Thesis

Degree Name

M.S. in Chemistry and Biochemistry

Organizational Unit

College of Natural Science and Mathematics, Chemistry and Biochemistry

First Advisor

Brady T. Worrell

Second Advisor

Brian Michel

Third Advisor

Allegra Aron

Fourth Advisor

Eric Kushner

Copyright Statement / License for Reuse

All Rights Reserved
All Rights Reserved.

Keywords

Cellular delivery, Micelles, Polymers, Carbon monoxide, Therapeutic agent

Abstract

Carbon monoxide (CO), traditionally known as a toxic gas, has emerged as a potential therapeutic agent due to its cytoprotective, anti-inflammatory, and vasodilatory properties. This study explores the development of CO-releasing polymeric micelles as a controlled delivery system for biomedical applications. Using ring-opening metathesis polymerization (ROMP), we synthesized diblock copolymers incorporating CO-releasing moiety diphenylcyclopropenone (DPCP) with hydrophilic polyethylene glycol (PEG) to enhance solubility and stability of the overall CO releasing system. Dynamic light scattering (DLS) and electron microscopy (EM) confirmed the formation of well-defined micelles, while fluorescence assays demonstrated efficient CO release with the use of Iridium photocatalyst under 470 nm light irradiation. Cellular studies using A549 cells validated CO uptake and non-toxic behavior. This research highlights the potential of polymeric micelles based on DPCP for controllable CO delivery, paving the way for safer and more effective therapeutic application.

Copyright Date

6-2025

Publication Statement

Copyright is held by the author. User is responsible for all copyright compliance.

Rights Holder

Riya Joshi

Provenance

Received from ProQuest

File Format

application/pdf

Language

English (eng)

Extent

108 pgs

File Size

6.3 MB

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